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This research focuses on the design and cost analysis of an energy-efficient Heating, Ventilation, and Air Conditioning (HVAC) system tailored for a six-story commercial building located in Aurangabad, Maharashtra. A detailed heat load analysis was conducted considering solar radiation, occupancy, lighting, equipment, and outdoor conditions. The resulting total cooling load was 114 TR (1,359,937 BTU/hr). To optimize system performance and minimize lifecycle costs, a Variable Refrigerant Flow (VRF) system was selected. Cost analysis shows that installation expenses range between ₹5.7 to ₹6.9 million, depending on the design parameters. The integration of climate-specific adaptations ensures year-round operational efficiency. This research provides a structured framework for developing sustainable HVAC solutions in commercial buildings in similar climatic zones. A key aspect of this design is its site-specific adaptation, considering the climate and environmental conditions unique to Location. This localized approach ensures that the HVAC system operates efficiently throughout the year, maximizing energy savings. The analysis also underscores the importance of conducting a detailed economic evaluation to ensure the system's long-term economic viability. This study adds to sustainable building practices by integrating energy optimization and economic analysis into HVAC system design, promoting greater efficiency and reduced environmental impact.